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You are here: Home / Archives for sleep patterns

Are You Cursed with a Night Owl Gene Mutation?

April 11, 2017 By Morning Health Team 23 Comments

Image result for night owl

Are you one of those people that seem to just naturally stay up late and consequently get up late? Have you ever wondered why you may be that way?

For years, we were told that it was the way you were raised. I know with me it was. I grew up having to do chores before school, so I had to get up early in order to do chores, have breakfast, fix my lunch and get to school on time. My chores usually consisted of taking care of animals – feeding and watering them and making sure they have everything they need. As I made it to college, I preferred early classes over later classes, so again, I was up early. I spent 12 years working for a utility. During the winter, we started work at 7am and in the summer, since Arizona does not observe Daylight Savings Time, we started work at 5am and were able to head home at the peak heat of the day.

These days, I’m 65 years old and I still habitually get up early, even if I don’t have to. I always thought that since I got up early most of my life that it’s a habit that I still have.

Our two daughters, born 16 months apart are as different as night and day. As a child, our oldest daughter would disappear between 8pm and 9pm. When we went looking for her, we always found her in bed, sound asleep. Rarely did we ever have to tell her to go to bed.

On the flip side, our youngest daughter always fought going to bed and when we put her to bed, she would be awake for hours. During her school days, we often found her with a light on at midnight reading a book and we would have to tell her to turn the light off and go to bed. In the morning, she never wanted to get up. She is 39-years-old now and still cannot go to sleep early or at normal times but stays up late and doesn’t like to get up early.

As parents, we could never figure out why such a difference between the two girls. A new study may finally give us the answer we’ve sought all these years.

Researchers at the Laboratory of Genetics at The Rockefeller University just authored a study on a sleep disorder called ‘delayed sleep phase disorder’ (DSPD). People with this sleep disorder tend to do some of the best work late at night and struggle to wake up and get going in the morning.

Researchers studied 70 people from six families and found that those individuals with DSPD had a mutation on a gene known as CRY1. Members of the same families that did not exhibit the DSPD sleep disorder did not have the mutation on the CRY1 gene.

The researchers reported that this is the first time a gene mutation has been identified as a cause of DSPD. The mutation disrupts the body’s natural circadian rhythm, also known by some people as their internal clock. Our natural circadian rhythm is hardwired into our genetics and it is programmed to operate in 24-hour cycles. However at least 10% of people with DSPD operate on an internal clock that operates in a longer than a 24-hour loop.

Alina Patke, lead author of the study, commented, saying:

“Carriers of the mutation have longer days than the planet gives them, so they are essentially playing catch-up for their entire lives.”

“A person like a bartender, for example, might not experience any problem with the delayed sleep cycle. but someone like a surgeon who has to be in the OR in the early morning – that’s not compatible.”

Their discovery was first made when a 46-year-old woman came to a sleep clinic for help after years of struggling with her late sleep cycle. They placed her in an apartment for two-weeks. The apartment had no windows or connections to the outside world. No television, internet; nothing that might hint as to the time of day.

Under the study conditions, they discovered the woman’s sleep cycle operated on about a 25-hour clock instead of 24-hour. Consequently, her sleep was often fragmented, leaving her constantly feeling tired. It was after this two-week testing that the researcher sequenced her genes and discovered the CRY1 genetic mutation.

To test their theory, they then contacted the 70 family members in the 6 families in Turkey and were able to conduct genetic sequencing on them and interviewed all of them concerning their sleep habits. Of the 70 test subjects, 39 contained the CRY1 mutation and 31 did not. Those that had the mutation had a later sleep cycle than those without the mutation.

If you are one of those night owl people who seem to naturally be wide awake late at night and struggle to get up in the morning for work or school, it may be that you are cursed with the CRY1 mutation. I wonder how many employers or teachers will buy that excuse for being late when you drop it on them?

Filed Under: Health, News Tagged With: delayed sleep phase disorder, gene mutation, night owl, research, sleep patterns, sleeping

Time Zones & Sleeping in on Weekends Can Increase Risk of Cancer and More

April 7, 2017 By Morning Health Team 1 Comment

 

Image result for sleeping

For the past decade, we’ve been hearing a lot about getting enough sleep and what lack of sleep can do physically and mentally to a person. Most experts say that we should be getting 7-8 hours of quality sleep a night. Not getting enough sleep can make a person more susceptible to obesity, diabetes and increase the risk of some cancers and heart conditions. It also leaves a person mentally fatigued, interfering with their ability to function at the level they should be functioning at.

Allow me to say just how true this is…

About 15 years ago, I was sent to a sleep clinic by my doctor because my wife said I stopped breathing a lot when I slept. After the tests, the sleep clinic doctor shared the good and bad news with me. I had three separate and distinct sleep disorders, the worst of which was sleep apnea (this is the one where you stop breathing many times while sleeping). However, he then said that he could treat the sleep apnea or the other two, but it’s not possible to treat all three at the same time. So, I sleep with a CPAP machine that forces air into my nose and keeps me from stopping to breathe. The doctor also told me that to treat the sleep apnea, it can aggravate the other two disorders which he described as minor. The CPAP machine did help, but I also live in constant severe pain which also prevents me from sleeping well. On a good night, I am fortunate if I get a total of 4 hours of sleep during 8 hours of trying to sleep. Consequently, I am constantly fatigued and often fall asleep quite easily. Basically, I’m so tired that I can’t stay awake and but hurt so much I can’t stay asleep. Yes, I am obese, have Type-2 diabetes and my immune system is very compromised making me very susceptible to every bug that goes around.

With all that said, have you ever heard of ‘social jet lag’? It has nothing to do with flying in a plane from one time zone to another. Social jet lag is defined as getting up at a certain time during the week and then sleeping in on the weekends. While many people do this to catch up on their sleep, it is actually proving to interrupt our body’s circadian rhythm. Many functions in your body are controlled by your circadian rhythm.

According to one source:

    Circadian rhythm:

    A circadian rhythm is a roughly 24-hour cycle in the physiological processes of living beings, including plants, animals, fungi and cyanobacteria.

    In a strict sense, circadian rhythms are endogenously generated, although they can be modulated by external cues such as sunlight and temperature.

    Circadian rhythms are important in determining the sleeping and feeding patterns of all animals, including human beings.

    There are clear patterns of brain wave activity, hormone production, cell regeneration and other biological activities linked to this daily cycle.

Breaking up the circadian rhythm disrupts the natural cycle of how and when things work in our bodies. This is why rotating shifts are very bad on one’s health, as is social jet lag.

But did you know that where you live in a time zone can also affect your circadian rhythm which in turn may increase your chances of developing a number of health conditions including cancer?

For example, take the Eastern Time Zone. It reaches from the east coast westward. A person living in the eastern part of the time, say Boston, gets up at 8am and it is daylight. The daylight helps trigger the circadian rhythm processes. Yet a person living in Ohio or northern Kentucky also in the Eastern Time Zone, who gets up at 8am may find that it’s still dark outside. Hence the activity of getting up and the darkness work oppositely on the circadian rhythm. One researcher said that for every 5 degrees of longitude westward within a time zone is equal to a 20-minute delay in sunrise.

While you may be saying big deal, you may find what else the research found to be insightful:

    Social jet lag has been linked to various conditions including obesity and diabetes, Caporaso said. In the new study, the researchers focused on cancer.

    Cancer and the biological clock

    In the study, the researchers looked at data on 4 million white adults who had been diagnosed with cancer between 2000 and 2012. The people in the study lived in more than 600 counties in 11 states, all within the continental U.S.

    Results showed that for every 5 degrees of longitude toward the west that a person lived from the eastern edge of their time zone, his or her risk of developing any type of cancer increased by 3 percent in men and 4 percent in women.

    The researchers also looked at people’s risk of developing specific cancers.

    For example, men who lived in the western-most region of a time zone had a 4 percent greater risk of prostate cancer, and 13 percent greater risk of chronic lymphocytic leukemia, a cancer that affects white blood cells, compared with men who lived in the eastern-most regions of a time zone, the researchers found.

    Women living in the western-most regions had a 4 percent greater risk of breast cancer, a 12 percent greater risk of chronic lymphocytic leukemia and a 10 percent greater of a type of uterine cancer compared with women living in the eastern-most region of a time zone, the researchers found.

Keeping to a set schedule of getting up at the same time every day is much healthier than sleeping in on the weekends, but then again so is living towards the eastern edge of your time-zone.

Filed Under: Health, Wellness Tagged With: cancer, circadian rhythm, diabettes, sleep loss, sleep patterns, sleeping on weekends

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